Best Advice for People Taking Opioid Medication It"s official: Prince died of an overdose from opioid painkillers, becoming the latest high-profile victim of America"s opioid epidemic.Prince died unexpectedly at his home in Minnesota on April 21. A law enforcement official on Thursday confirmed to the Associated Press that, based on autopsy tests, Prince died of an opioid overdose.Prince had been reportedly trying to check...